Pyoderma Gangrenosum keratosis{ PGK} can be described as a rare ulcerative cutaneous condition of the skin. It evolves spontaneously in most patients and it is also characterized by malignancy, vasculitis and collagen vascular disorders. The ulceration effect may occur after an individual suffer an injury to the skin. The two main primary variants of PG Keratosis are observed mostly on the legs, and the more superficial variant is mostly found on the hands. It has been found that patients who suffer PG Keratosis may have some of their body organs suffering from some forms of sterile neutrophilic abscesses. The liver, the kidney, the central nervous system, lymph nodes, the spleen and the bones may be involved in the development of PG Keratosis.
In most cases, the most prominent therapies used in the treatment of this keratosis are anti-inflammatory agents such as immuno-suppressive agents and corticosteroids. Though the pathology of PG Keratosis is hardly understood, however the irregularities of the body’s immune system is clearly implicated in the disorder. It is believed that Pyoderma occur in 1 out of every 100,000 people annually , and the death of an individual due to the infection is very rare. Most patient often complain of pains and as such may require narcotics in the treatment of Pyoderma Gangrenosum. The lesions at the site of infection may create some problems with wound healing especially after surgical procedures to remove such.
A typical PGK infection may appear typically appear at the dorsal surface of the hands, or the extensor part of the forearms or face. The classic forms of PGK may appear at the stoma sites, this is often mistaken for an ordinary wound but it is not as it can become more prominent in weeks. Vulvar or penile Pyoderma are the common genital pyodermal infections which occur most especially around the genital regions, the intra-oral form of the disease are often reported in patients suffering from irritable bowel syndrome, it has also been reported to affect some other organs of the body including the lungs, bones and liver.
Ocular investigation and examination is one of the reliable ways through which Pyoderma Gangrenosum can be detected. It has also been discovered that trauma problems in people who are suffering from Pyoderma Gangrenosum can induce fresh pyoderma infection on the skin, hence effort is often made to ensure during treatment that unaffected skin regions are not subjected to any form of pressure.
